AED | Audio Epilepsy Digest Episode 010 Companion

AED Quiz

A Positive Signal With a Negative Primary Endpoint: The NAUTILUS Trial

Self-assessment questions on endpoint hierarchy, randomized evidence, and bounded counseling after NAUTILUS.

This AED Quiz is for self-assessment and journal-club discussion. It is not accredited CME and does not provide CME credit.
EpisodeA Positive Signal With a Negative Primary Endpoint: The NAUTILUS Trial
ReviewAI editorial/source review
ListenCanonical audio file

Learning Objectives

  1. Interpret NAUTILUS using endpoint hierarchy.
  2. Distinguish randomized evidence from case-series and meta-analytic context.
  3. Frame thalamic RNS for IGE as a bounded counseling/referral discussion, not established standard care.

Questions

1. Which statement best describes the NAUTILUS trial result emphasized in this activity?
Correct answer: B. The key appraisal point is endpoint hierarchy: safety was met, the prespecified primary effectiveness endpoint was not statistically significant, and longer-term signals remain bounded.
2. When counseling a selected patient with drug-resistant IGE and recurrent GTCS after NAUTILUS, which framing is most appropriate?
Correct answer: B. The narrow implication is careful discussion and referral consideration, not a guideline-level recommendation.
3. Which source type should carry the most weight for efficacy interpretation in this episode?
Correct answer: C. Context sources explain plausibility, but the randomized sham-controlled trial and its prespecified endpoints anchor efficacy interpretation.

Reflection

What would change how you discuss this episode's evidence in journal club, clinic, or surgical conference?

Review Basis

Questions were drafted from the release show note, episode source-review boundary, and available episode planning materials. The page is intentionally framed as self-assessment, not accredited CME.