AED Quiz | Episode 11 | Audio Epilepsy Digest

1. What is the safest clinical framing for GLP-1 receptor agonist findings in the episode? They support prescribing GLP-1 drugs for seizure control. They are hypothesis-generating signals, not seizure-treatment evidence. They prove cardiovascular outcome trials were epilepsy-prevention trials. They establish GLP-1 drugs as antiseizure medications.

Correct answer: B. The episode repeatedly holds GLP-1 findings in the signal-before-practice-change lane.

2. How should the AbuAlrob seizure-recurrence result be communicated? As a guaranteed 18% absolute seizure reduction. As an estimated 18% lower hazard with about a 2.1 percentage-point absolute recurrence difference. As seizure-diary adjudicated proof of efficacy. As evidence that all people with epilepsy should start GLP-1 therapy.

Correct answer: B. The show note preserves both the relative hazard estimate and the smaller absolute difference.

3. What is the right interpretation of VNS predictor evidence? It creates a deterministic five-year implantation window rule. It offers research signals that should not be converted into hard implantation rules. It proves VNS should be avoided outside the predictor-positive group. It removes the need for individualized counseling.

Correct answer: B. The episode warns against over-reading VNS prognostic factors into deterministic rules.

Signals Before Practice Change: GLP-1 Drugs and the Temptation to Overread

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